BDBM50065306 3-[4-(1-formylpiperazin-4-yl)benzylidenyl]-2-indolinone::4-{4-[2-Oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-phenyl}-piperazine-1-carbaldehyde::CHEMBL315546::SU-4984
SMILES O=CN1CCN(CC1)c1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
InChI Key InChIKey=ZNFJBJDODKHWED-AQTBWJFISA-N
Data 11 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50065306
Affinity DataIC50: 5.13E+3nMAssay Description:Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1)More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
New York University Medical Center
Curated by ChEMBL
New York University Medical Center
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1K (unknown origin) autophosphorylation activity assessed as [32P] incorporationMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Mus musculus)
New York University Medical Center
Curated by ChEMBL
New York University Medical Center
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of acidic FGF-stimulated FGFR1 tyrosine autophosphorylation in mouse NIH/3T3 cells by immunoblottingMore data for this Ligand-Target Pair
Affinity DataIC50: 5.10E+3nMAssay Description:Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptorMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
New York University Medical Center
Curated by ChEMBL
New York University Medical Center
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1 kinase domain (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).More data for this Ligand-Target Pair
Affinity DataIC50: 9.02E+4nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Milano-Bicocca
Curated by ChEMBL
University Of Milano-Bicocca
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Mus musculus)
New York University Medical Center
Curated by ChEMBL
New York University Medical Center
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of FGF induced FGFR1 autophosphorylation in mouse NIH 3T3 cells preincubated for 5 mins followed by FGF-stimulation for 5 mins in presence...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair