BDBM50066494 CHEMBL116816::N*6*-(2,5-Dimethoxy-benzyl)-quinazoline-2,4,6-triamine::N6-(2,5-dimethoxybenzyl)quinazoline-2,4,6-triamine

SMILES COc1ccc(OC)c(CNc2ccc3nc(N)nc(N)c3c2)c1

InChI Key InChIKey=HLVXCAKKBNEDDK-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50066494   

TargetDihydrofolate reductase(Lactobacillus casei)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066494(CHEMBL116816 | N*6*-(2,5-Dimethoxy-benzyl)-quinazo...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Lactobacillus casei (lcDHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066494(CHEMBL116816 | N*6*-(2,5-Dimethoxy-benzyl)-quinazo...)
Affinity DataIC50:  420nMAssay Description:Inhibitory activity against recombinant Dihydrofolate reductase from Escherichia coli (ecDHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066494(CHEMBL116816 | N*6*-(2,5-Dimethoxy-benzyl)-quinazo...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066494(CHEMBL116816 | N*6*-(2,5-Dimethoxy-benzyl)-quinazo...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii (pcDHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066494(CHEMBL116816 | N*6*-(2,5-Dimethoxy-benzyl)-quinazo...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Lactobacillus casei (lcDHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066494(CHEMBL116816 | N*6*-(2,5-Dimethoxy-benzyl)-quinazo...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibitory activity against Dihydrofolate reductase from rat liver (rlDHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066494(CHEMBL116816 | N*6*-(2,5-Dimethoxy-benzyl)-quinazo...)
Affinity DataIC50:  160nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066494(CHEMBL116816 | N*6*-(2,5-Dimethoxy-benzyl)-quinazo...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066494(CHEMBL116816 | N*6*-(2,5-Dimethoxy-benzyl)-quinazo...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066494(CHEMBL116816 | N*6*-(2,5-Dimethoxy-benzyl)-quinazo...)
Affinity DataIC50:  160nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066494(CHEMBL116816 | N*6*-(2,5-Dimethoxy-benzyl)-quinazo...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066494(CHEMBL116816 | N*6*-(2,5-Dimethoxy-benzyl)-quinazo...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066494(CHEMBL116816 | N*6*-(2,5-Dimethoxy-benzyl)-quinazo...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed