BDBM50072073 CHEMBL3407848

SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)nc3)c2cc1OC

InChI Key InChIKey=PVNWAPAWLNSQHB-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50072073   

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50072073(CHEMBL3407848)
Affinity DataIC50:  4nMAssay Description:Inhibition of human N-terminal His-tagged PERK expressed in Escherichia coli using AviTag C-terminal, N-terminal His-tagged eIF2alpha (3 to 315) as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargeteIF-2-alpha kinase GCN2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50072073(CHEMBL3407848)
Affinity DataIC50:  290nMAssay Description:Inhibition of human C-terminal His-tagged GCN2 expressed in Escherichia coli using AviTag C-terminal, N-terminal His-tagged eIF2alpha (3 to 315) as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50072073(CHEMBL3407848)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of IRE-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50072073(CHEMBL3407848)
Affinity DataEC50:  520nMAssay Description:Inhibition of PERK-mediated protein synthesis in human U2OS cells harboring thapsigargin-induced ER stress assessed as incorporation of L-azidohomoal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50072073(CHEMBL3407848)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HRI (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50072073(CHEMBL3407848)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant BRAF V600E kinase domain mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50072073(CHEMBL3407848)
Affinity DataIC50:  4.80E+5nMAssay Description:Inhibition of PKR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed