BDBM50073570 2-(4-Furan-2-yl-piperazin-1-yl)-6,7-dimethoxy-quinazolin-4-ylamine::CHEMBL137598

SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)c1ccco1

InChI Key InChIKey=WESSELXZMWZPLT-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50073570   

TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Recordati

Curated by ChEMBL
LigandPNGBDBM50073570(2-(4-Furan-2-yl-piperazin-1-yl)-6,7-dimethoxy-quin...)
Affinity DataKi:  0.460nMAssay Description:The binding affinity of the compound was determined towards Alpha-1B adrenergic receptor in the COS cell line.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Recordati

Curated by ChEMBL
LigandPNGBDBM50073570(2-(4-Furan-2-yl-piperazin-1-yl)-6,7-dimethoxy-quin...)
Affinity DataKi:  0.720nMAssay Description:The binding affinity of the compound was determined towards Alpha-1A adrenergic receptor in the COS cell line.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Recordati

Curated by ChEMBL
LigandPNGBDBM50073570(2-(4-Furan-2-yl-piperazin-1-yl)-6,7-dimethoxy-quin...)
Affinity DataKi:  1.39nMAssay Description:The binding affinity of the compound was determined towards Alpha-1C adrenergic receptor in the COS cell line.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Recordati

Curated by ChEMBL
LigandPNGBDBM50073570(2-(4-Furan-2-yl-piperazin-1-yl)-6,7-dimethoxy-quin...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory concentration against Dopamine receptor D2 (Inactive at >1000 nM concentration)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Recordati

Curated by ChEMBL
LigandPNGBDBM50073570(2-(4-Furan-2-yl-piperazin-1-yl)-6,7-dimethoxy-quin...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory concentration against 5-hydroxytryptamine 1A receptor (Inactive at >1000 nM concentration)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Recordati

Curated by ChEMBL
LigandPNGBDBM50073570(2-(4-Furan-2-yl-piperazin-1-yl)-6,7-dimethoxy-quin...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory concentration against 5-hydroxytryptamine 2A receptor (Inactive at >1000 nM concentration)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed