BDBM50075457 CHEMBL3415333

SMILES O=C1NC(=O)N(C2CCN(C(=O)C34CC5CC(CC3C5)C4)CC2)C1Cc1ccc(OS(=O)(=O)c2cccc3cnccc23)cc1

InChI Key InChIKey=XIXQJRALEZXJKQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50075457   

TargetP2X purinoceptor 7(Human)
Gwangju Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50075457BDBM50075457(CHEMBL3415333)
Affinity DataIC50: 49nMAssay Description:Antagonist activity at P2X7 receptor in LPS/IFN-gamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Gwangju Institute of Science and Technology (Gist)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50075457BDBM50075457(CHEMBL3415333)
Affinity DataIC50: 69nMAssay Description:Antagonist activity at recombinant human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced intracellular ethidium bromi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed