BDBM50076451 CHEMBL3235887::US10208043, # 14::US10941146, # 14

SMILES Oc1c(Sc2nc[nH]n2)cc(NS(=O)(=O)c2ccc(Br)cc2)c2ccccc12

InChI Key InChIKey=JRDUVAUQGLWQSV-UHFFFAOYSA-N

Data  7 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50076451   

TargetHistone acetyltransferase GCN5(Saccharomyces cerevisiae S288c)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50076451(CHEMBL3235887 | US10208043, # 14 | US10941146, # 1...)
Affinity DataIC50:  910nMAssay Description:Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using Asf1-dH3-H4 as substrate assessed as coenz...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase GCN5(Saccharomyces cerevisiae S288c)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50076451(CHEMBL3235887 | US10208043, # 14 | US10941146, # 1...)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using Asf1-dH3-H4 as substrate assessed as coenz...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase GCN5(Saccharomyces cerevisiae S288c)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50076451(CHEMBL3235887 | US10208043, # 14 | US10941146, # 1...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using [3H]-acetyl-CoA assessed as acetate incorp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFascin(Homo sapiens (human))
Novita Pharmaceuticals

US Patent
LigandPNGBDBM50076451(CHEMBL3235887 | US10208043, # 14 | US10941146, # 1...)
Affinity DataIC50:  2.62E+3nMAssay Description:A high throughput assay was developed to screen for fascin specific inhibitors. Purified polymerized F-actin with or without fascin were mixed and in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone acetyltransferase GCN5(Saccharomyces cerevisiae S288c)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50076451(CHEMBL3235887 | US10208043, # 14 | US10941146, # 1...)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of yeast histone acetyltransferase Gcn5-Ada2-Ada3 complex using tetramer and [3H]-acetyl-CoA assessed as acetate incorporation after 30 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFascin(Homo sapiens (human))
Novita Pharmaceuticals

US Patent
LigandPNGBDBM50076451(CHEMBL3235887 | US10208043, # 14 | US10941146, # 1...)
Affinity DataIC50:  2.62E+3nMAssay Description:About 150,000 compounds were screened. These chemical compounds were from the LOPAC 1280 collection, the Prestwick chemical library, the Pharmakon co...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50076451(CHEMBL3235887 | US10208043, # 14 | US10941146, # 1...)
Affinity DataKd:  1.31E+4nMAssay Description:Inhibition of Keap1-Nrf2 (unknown origin) interaction assessed as compound's equilibrium dissociation constant after 60 mins by fluorescence anisotro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50076451(CHEMBL3235887 | US10208043, # 14 | US10941146, # 1...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed