BDBM50083894 7-Ethynyl-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one(Q-II-66)::7-ethynyl-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one::CHEMBL174535

SMILES CN1c2ccc(cc2C(=NCC1=O)c1ccccc1)C#C

InChI Key InChIKey=FESCSZDQOFYRDR-UHFFFAOYSA-N

Data  9 KI  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50083894   

TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50083894(7-Ethynyl-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1...)
Affinity DataKi:  6.80nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-5-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50083894(7-Ethynyl-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1...)
Affinity DataKi:  6.80nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha5beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50083894(7-Ethynyl-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1...)
Affinity DataKi:  42nMAssay Description:Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50083894(7-Ethynyl-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1...)
Affinity DataKi:  42nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha2beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-2/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50083894(7-Ethynyl-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1...)
Affinity DataKi:  47nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha3beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50083894(7-Ethynyl-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1...)
Affinity DataKi:  47nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-3-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50083894(7-Ethynyl-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1...)
Affinity DataKi:  76nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha1beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50083894(7-Ethynyl-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1...)
Affinity DataKi:  76nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-1-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50083894(7-Ethynyl-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1...)
Affinity DataKi: >3.00E+3nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Moltech

Curated by ChEMBL
LigandPNGBDBM50083894(7-Ethynyl-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1...)
Affinity DataKd:  76nMAssay Description:Binding affinity to GABAA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Moltech

Curated by ChEMBL
LigandPNGBDBM50083894(7-Ethynyl-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1...)
Affinity DataKd:  7nMAssay Description:Binding affinity to GABAA alpha-5-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed