BDBM50085047 2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl ester::2-(p-Chlorophenoxy)-2-methylpropionic acid ethyl ester::CHEMBL565::Clofibrate::EPIB::ETHYL CLOFIBRATE::Ethyl 2-(p-chlorophenoxy)isobutyrate::Ethyl chlorophenoxyisobutyrate::Liprin::alpha-(p-Chlorophenoxy)isobutyric acid, ethyl ester::alpha-p-Chlorophenoxyisobutyryl ethyl ester::ethyl 2-(4-chlorophenoxy)-2-methylpropanoate

SMILES CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1

InChI Key InChIKey=KNHUKKLJHYUCFP-UHFFFAOYSA-N

Data  2 KI  8 IC50  8 Kd  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50085047   

TargetFatty acid-binding protein, liver(Rattus norvegicus (Rat))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataKi:  6.92E+3nMAssay Description:Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier organic anion transporter family member(Danio rerio (Zebrafish))
Rudjer Boskovic Institute

LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataKi:  3.45E+5nMAssay Description:In the inhibition experiments, the cells were preincubated for 20 s with test compounds, followed by a 5-min incubation with [3H]E3S (5 nM) or 30-min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataIC50:  8.60E+5nMAssay Description:Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of nonsaponifiable lipid synthesis using [2-14C]ac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Glaxo Wellcome Research & Development

Curated by ChEMBL
LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataEC50:  5.50E+4nMAssay Description:Agonist activity for Human PPAR alpha receptor in transcriptional activation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Mus musculus)
Glaxo Wellcome Research & Development

Curated by ChEMBL
LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataEC50:  5.00E+5nMAssay Description:Agonist activity for murine PPAR gamma receptor in transcriptional activation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Mus musculus)
Glaxo Wellcome Research & Development

Curated by ChEMBL
LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataEC50:  5.00E+4nMAssay Description:Agonist activity for murine PPAR alpha receptor in transcriptional activation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research & Development

Curated by ChEMBL
LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataEC50:  5.00E+5nMAssay Description:Agonist activity for Human PPAR gamma receptor in transcriptional activation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Glaxo Wellcome Research & Development

Curated by ChEMBL
LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataEC50:  5.50E+4nMAssay Description:Effective concentration against human peroxisome proliferator activated receptor alpha in Gal4 transactivation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid-binding protein, liver(Rattus norvegicus (Rat))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataKd:  6.00E+3nMAssay Description:Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 5 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid-binding protein, liver(Rattus norvegicus (Rat))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataKd:  6.70E+3nMAssay Description:Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 10 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid-binding protein, liver(Rattus norvegicus (Rat))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataKd:  7.30E+3nMAssay Description:Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 15 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid-binding protein, liver(Rattus norvegicus (Rat))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataKd:  7.80E+3nMAssay Description:Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 20 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid-binding protein, liver(Rattus norvegicus (Rat))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataKd:  8.90E+3nMAssay Description:Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 25 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid-binding protein, liver(Rattus norvegicus (Rat))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataKd:  9.60E+3nMAssay Description:Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 30 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid-binding protein, liver(Rattus norvegicus (Rat))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataKd:  1.10E+4nMAssay Description:Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 37 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid-binding protein, liver(Rattus norvegicus (Rat))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataKd:  1.20E+4nMAssay Description:Binding affinity to rat recombinant L-FABP high affinity site expressed in Escherichia coli BL21(DE3) at 42 deg C by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Glaxo Wellcome Research & Development

Curated by ChEMBL
LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataEC50:  5.50E+4nMAssay Description:Agonist activity at PPARalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataIC50:  6.00E+4nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataIC50:  7.10E+4nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataIC50:  6.30E+5nMAssay Description:Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of total lipid synthesis using [2-14C]acetate as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Mus musculus)
Glaxo Wellcome Research & Development

Curated by ChEMBL
LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataEC50:  5.50E+7nMAssay Description:Agonist activity at mouse PPARalphaMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50085047(2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl e...)
Affinity DataIC50:  4.40E+5nMAssay Description:Inhibition of HMG-coA reductase in CD rat liver microsomal-cytosol fraction assessed as inhibition of fatty acid synthesis using [2-14C]acetate as su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed