BDBM50085452 (S)-2-[((S)-6-Amino-2-methanesulfonylamino-hexanoylamino)-methyl]-3-{1-[(S)-1-carboxy-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-cyclopentyl}-propionic acid::CHEMBL42583::Sampatrilat
SMILES CS(=O)(=O)N[C@@H](CCCCN)C(=O)NC[C@H](CC1(CCCC1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)C(O)=O
InChI Key InChIKey=LPUDGHQMOAHMMF-JBACZVJFSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50085452
Affinity DataKi: 14nMAssay Description:Inhibition of human testis ACE C-domain lacking unique O-glycosylated region, transmembrane anchor and cytoplasmic tail expressed in CHO cells using ...More data for this Ligand-Target Pair
Affinity DataKi: 172nMAssay Description:Inhibition of human somatic ACE N-domain soluble form (1 to 629 residues) expressed in CHO cells using Z-FHL as substrate preincubated with enzyme fo...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:In vitro inhibition of phosphoramidon-sensitive membrane bound zinc metalloprotease Endothelin-converting enzyme from partially purified guinea pig l...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of NEP (unknown origin)More data for this Ligand-Target Pair
TargetNeprilysin(Rattus norvegicus (Rat))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of Neutral endopeptidaseMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of Angiotensin I converting enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Inhibition of atrial natriuretic peptideMore data for this Ligand-Target Pair