BDBM50086042 (R)-1-{3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bicyclo[3.2.1]oct-8-ylmethyl}-2-methyl-propylamine::CHEMBL429015

SMILES CC(C)[C@@H](N)CN1C2CCC1CC(C2)OC(c1ccc(F)cc1)c1ccc(F)cc1

InChI Key InChIKey=FJEFLHYWSUMBKN-GVWQBGCGSA-N

Data  6 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50086042   

TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50086042((R)-1-{3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bic...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]WIN35428 from Sprague-Dawley rat brain DAT after 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50086042((R)-1-{3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bic...)
Affinity DataKi:  56.4nMAssay Description:Displacement of [3H]WIN-35428 from the dopamine transporter in rat caudate putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50086042((R)-1-{3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bic...)
Affinity DataKi:  81nMAssay Description:Inhibition of [3H]WIN5428 uptake at wild type human DAT expressed in African green monkey COS7 cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50086042((R)-1-{3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bic...)
Affinity DataKi:  133nMAssay Description:Inhibition of [3H]DA uptake at wild type human DAT expressed in African green monkey COS7 cells after 5 mins by beta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50086042((R)-1-{3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bic...)
Affinity DataKi:  2.18E+3nMAssay Description:Binding affinity at Muscarinic acetylcholine receptor M1 in Rat brain homogenate by [3H]pirenzepine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50086042((R)-1-{3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bic...)
Affinity DataKi:  3.87E+3nMAssay Description:Displacement of [3H]citalopram from Sprague-Dawley rat brain SERT after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50086042((R)-1-{3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bic...)
Affinity DataIC50:  4.36E+3nMAssay Description:Displacement of [3H]Dofetilide from human ERG expressed in HEK cells after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed