BDBM50090808 CHEMBL319825::[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid phenyl ester

SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)Oc3ccccc3)c2c1

InChI Key InChIKey=QDAPTCCLPDRQOA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50090808   

TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50090808(CHEMBL319825 | [1-(4-Chloro-benzoyl)-5-methoxy-2-m...)
Affinity DataIC50: >6.60E+4nMAssay Description:In vitro inhibitory activity against ovine Prostaglandin G/H synthase 1 (44 nM) using [14C]AA (50 uM) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50090808(CHEMBL319825 | [1-(4-Chloro-benzoyl)-5-methoxy-2-m...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human COX2 expressed in SF-9 insect cells assessed as conversion of [14C]-arachidonic acid to [14C]-prostaglandins preincubated for 20 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50090808(CHEMBL319825 | [1-(4-Chloro-benzoyl)-5-methoxy-2-m...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of ram seminal vesicle COX1 assessed as conversion of [14C]-arachidonic acid to [14C]-prostaglandins preincubated for 20 mins by thin-laye...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50090808(CHEMBL319825 | [1-(4-Chloro-benzoyl)-5-methoxy-2-m...)
Affinity DataIC50:  400nMAssay Description:In vitro inhibitory activity against human Prostaglandin G/H synthase 2 (66 nM) using [14C]-AA (50 uM) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed