BDBM50092079 CHEMBL3582439
SMILES Fc1cccc(c1)[C@H]1CCCN1c1ccc2ncc(-c3ccccn3)n2n1
InChI Key InChIKey=RKERQEKFTWWCEY-GOSISDBHSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 19 hits for monomerid = 50092079
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of Tel-fused FLT3 (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant...More data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of Tel-fused TRKB (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...More data for this Ligand-Target Pair
TargetInsulin receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of Tel-fused INSR (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of Tel-fused FGFR3 (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinan...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of Tel-fused MET (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant ...More data for this Ligand-Target Pair
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Tel-fused BMX (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of Tel-fused RET (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant ...More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of Tel-fused KIT (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant ...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Tel-fused FMS (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of Tel-fused JAK2 (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 9.20E+3nMAssay Description:Inhibition of Tel-fused FGFR4 (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinan...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of NMP-fused ALK (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor Tie-1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of Tel-fused TIE1 (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of Tel-fused KDR (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant ...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of Tel-fused TRKA (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of Tel-fused FGR (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of Tel-fused LYN (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of Tel-fused ROS (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant ...More data for this Ligand-Target Pair
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of Tel-fused TRKC (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...More data for this Ligand-Target Pair