BDBM50093539 7,8-Dihydroxy-2-phenyl-chromen-4-one::7,8-Dihydroxyflavone::7,8-dihydroxy-2-phenyl-4H-chromen-4-one::CHEMBL75267

SMILES Oc1ccc2c(oc(cc2=O)-c2ccccc2)c1O

InChI Key InChIKey=COCYGNDCWFKTMF-UHFFFAOYSA-N

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50093539   

TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50093539(7,8-Dihydroxy-2-phenyl-chromen-4-one | 7,8-Dihydro...)
Affinity DataIC50:  3.14E+5nMAssay Description:Inhibition of p56 lckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Bu-Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50093539(7,8-Dihydroxy-2-phenyl-chromen-4-one | 7,8-Dihydro...)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of human telomerase from HEK293 cell extracts by Flash-Plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50093539(7,8-Dihydroxy-2-phenyl-chromen-4-one | 7,8-Dihydro...)
Affinity DataKd:  10nMAssay Description:Binding affinity to recombinant human TrkB receptor ECD assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50093539(7,8-Dihydroxy-2-phenyl-chromen-4-one | 7,8-Dihydro...)
Affinity DataKd:  320nMAssay Description:Binding affinity to TrkB receptor extracellular domain (unknown origin) after 10 mins by liquid Scatchard plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM50093539(7,8-Dihydroxy-2-phenyl-chromen-4-one | 7,8-Dihydro...)
Affinity DataIC50:  3.50E+5nMAssay Description:In vitro antibacterial activity was determined as inhibitory concentration causing 50% DNA-gyrase supercoiling inhibition (SCI)More data for this Ligand-Target Pair
In DepthDetails
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50093539(7,8-Dihydroxy-2-phenyl-chromen-4-one | 7,8-Dihydro...)
Affinity DataIC50:  9.82E+3nMAssay Description:Inhibition of IKK-beta using TMB substrate after 15 mins by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed