BDBM50097365 1-((1H-imidazol-1-yl)methyl)-9-oxo-9H-xanthene-4-carbonitrile::1-Imidazol-1-ylmethyl-9-oxo-9H-xanthene-4-carbonitrile::CHEMBL442373

SMILES O=c1c2ccccc2oc2c(ccc(Cn3ccnc3)c12)C#N

InChI Key InChIKey=ILCZWQUJENBNHZ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50097365   

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50097365(1-((1H-imidazol-1-yl)methyl)-9-oxo-9H-xanthene-4-c...)
Affinity DataIC50:  220nMAssay Description:Inhibition of human testicular microsome Steroid 17-alpha-hydroxylase/17,20 lyaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50097365(1-((1H-imidazol-1-yl)methyl)-9-oxo-9H-xanthene-4-c...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of human placental microsome cytochrome P450 19A1 aromataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50097365(1-((1H-imidazol-1-yl)methyl)-9-oxo-9H-xanthene-4-c...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of human aromatase-mediated conversion of [1beta3H]androstenedione to estrone by liquid scintillation counting in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50097365(1-((1H-imidazol-1-yl)methyl)-9-oxo-9H-xanthene-4-c...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50097365(1-((1H-imidazol-1-yl)methyl)-9-oxo-9H-xanthene-4-c...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of human placental CYP19 using [1beta-3H]androstenedione as substrate by 3H2O-methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50097365(1-((1H-imidazol-1-yl)methyl)-9-oxo-9H-xanthene-4-c...)
Affinity DataIC50:  220nMAssay Description:Inhibition of human CYP17 expressed in Escherichia coli co-expressing rat NADPH-P450-reductase using progesterone as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50097365(1-((1H-imidazol-1-yl)methyl)-9-oxo-9H-xanthene-4-c...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50097365(1-((1H-imidazol-1-yl)methyl)-9-oxo-9H-xanthene-4-c...)
Affinity DataIC50:  220nMAssay Description:In vitro inhibition of human Cytochrome P450 17A1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed