BDBM50097370 1-((1H-imidazol-1-yl)methyl)-4-bromo-9H-xanthen-9-one::4-Bromo-1-imidazol-1-ylmethyl-xanthen-9-one::CHEMBL78322

SMILES Brc1ccc(Cn2ccnc2)c2c1oc1ccccc1c2=O

InChI Key InChIKey=FSWPWGQUEZXZFV-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50097370   

TargetAromatase(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50097370(1-((1H-imidazol-1-yl)methyl)-4-bromo-9H-xanthen-9-...)
Affinity DataIC50:  940nMAssay Description:Inhibition of human placental microsome cytochrome P450 19A1 aromataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50097370(1-((1H-imidazol-1-yl)methyl)-4-bromo-9H-xanthen-9-...)
Affinity DataIC50:  42nMAssay Description:Inhibition of human testicular microsome Steroid 17-alpha-hydroxylase/17,20 lyaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50097370(1-((1H-imidazol-1-yl)methyl)-4-bromo-9H-xanthen-9-...)
Affinity DataIC50:  940nMAssay Description:Inhibition of human aromatase-mediated conversion of [1beta3H]androstenedione to estrone by liquid scintillation counting in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50097370(1-((1H-imidazol-1-yl)methyl)-4-bromo-9H-xanthen-9-...)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50097370(1-((1H-imidazol-1-yl)methyl)-4-bromo-9H-xanthen-9-...)
Affinity DataIC50:  940nMAssay Description:Inhibition of human placental CYP19 using [1beta-3H]androstenedione as substrate by 3H2O-methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50097370(1-((1H-imidazol-1-yl)methyl)-4-bromo-9H-xanthen-9-...)
Affinity DataIC50:  42nMAssay Description:Inhibition of human CYP17 expressed in Escherichia coli co-expressing rat NADPH-P450-reductase using progesterone as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50097370(1-((1H-imidazol-1-yl)methyl)-4-bromo-9H-xanthen-9-...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50097370(1-((1H-imidazol-1-yl)methyl)-4-bromo-9H-xanthen-9-...)
Affinity DataIC50:  42nMAssay Description:In vitro inhibition of human Cytochrome P450 17A1 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed