BDBM50098940 8-Fluoro-3-(4-fluoro-phenyl)-3,4-dihydro-isoquinolin-1-ylamine::CHEMBL7945
SMILES NC1=NC(Cc2cccc(F)c12)c1ccc(F)cc1
InChI Key InChIKey=LCRLDHTZCMPEPS-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50098940
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood
Curated by ChEMBL
Astrazeneca R&D Charnwood
Curated by ChEMBL
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by neuronal NOS (n NOS) from rat cerebellumMore data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Astrazeneca R&D Charnwood
Curated by ChEMBL
Astrazeneca R&D Charnwood
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Ability to inhibit conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cellsMore data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Astrazeneca R&D Charnwood
Curated by ChEMBL
Astrazeneca R&D Charnwood
Curated by ChEMBL
Affinity DataIC50: 3.50E+8nMAssay Description:Inhibitory concentration against nitric oxide synthesis in intact DLD-1 cellsMore data for this Ligand-Target Pair