BDBM50098962 5-Cyclopropyl-4,5-dihydro-thieno[2,3-c]pyridin-7-ylamine::CHEMBL8365

SMILES NC1=NC(Cc2ccsc12)C1CC1

InChI Key InChIKey=MSFKVTUZXYQWQW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50098962   

TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098962(5-Cyclopropyl-4,5-dihydro-thieno[2,3-c]pyridin-7-y...)
Affinity DataIC50:  50nMAssay Description:Ability to inhibit the conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by e-NOS from HUVECcellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098962(5-Cyclopropyl-4,5-dihydro-thieno[2,3-c]pyridin-7-y...)
Affinity DataIC50:  11nMAssay Description:Ability to inhibit the conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by n-NOS from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098962(5-Cyclopropyl-4,5-dihydro-thieno[2,3-c]pyridin-7-y...)
Affinity DataIC50:  51nMAssay Description:Ability to inhibit the conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by i-NOS from human DLD-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed