BDBM50099587 2-(4-Hydroxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-1H-indol-5-ol::CHEMBL44426::Pipendoxifene::US8815934, No. 107::US8815934, No. 97

SMILES Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCC3)cc2)c2ccc(O)cc12

InChI Key InChIKey=JICOGKJOQXTAIP-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50099587   

TargetEstrogen receptor(Homo sapiens (Human))
Wyeth

US Patent
LigandPNGBDBM50099587(2-(4-Hydroxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-...)
Affinity DataIC50:  60nMT: 2°CAssay Description:The competition assay was performed in a 96-well plate (polystyrene*) which binds <2.0% of the total input [3H]-17beta-estradiol and each data point ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth

US Patent
LigandPNGBDBM50099587(2-(4-Hydroxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-...)
Affinity DataIC50:  60nMT: 2°CAssay Description:The competition assay was performed in a 96-well plate (polystyrene*) which binds <2.0% of the total input [3H]-17beta-estradiol and each data point ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth

US Patent
LigandPNGBDBM50099587(2-(4-Hydroxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-...)
Affinity DataEC50:  0.100nMAssay Description:Induction of estrogen receptor-alpha degradation in human MCF7 cells after 4 hrs by in-cell western assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099587(2-(4-Hydroxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibitory concentration against [3H]-17-beta-estradiol binding to human estrogen receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth

US Patent
LigandPNGBDBM50099587(2-(4-Hydroxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-...)
Affinity DataIC50:  14nMAssay Description:In vitro inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth

US Patent
LigandPNGBDBM50099587(2-(4-Hydroxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-...)
Affinity DataIC50:  1.5nMAssay Description:In vitro antagonist effect on estrogen receptor alpha transcriptional activation in MCF-7 cells against 10 pM 17-beta-estradiolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed