BDBM50100312 4-Imidazol-1-ylmethyl-2-(2-methoxy-phenoxy)-benzonitrile::CHEMBL25550

SMILES COc1ccccc1Oc1cc(Cn2ccnc2)ccc1C#N

InChI Key InChIKey=ZDTTWZWUUZGVNX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50100312   

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50100312(4-Imidazol-1-ylmethyl-2-(2-methoxy-phenoxy)-benzon...)
Affinity DataIC50:  340nMAssay Description:Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50100312(4-Imidazol-1-ylmethyl-2-(2-methoxy-phenoxy)-benzon...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed