BDBM50101791 CHEMBL3394943

SMILES Cc1cn(cn1)-c1ccc2C(=O)N(Cc3cn(C)c4ccc(c(F)c34)C(F)(F)F)CCn2c1=O

InChI Key InChIKey=SOWUEDNFEKMNJN-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50101791   

TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

LigandBDBM50101791(CHEMBL3394943)Copy SMILESCopy InChI

Affinity DataIC50:  35nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells overexpressing human wild type APP assessed as reduction of amyloid beta 42 lev...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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