BDBM50103249 10-Methoxy-2,2,4-trimethyl-5-(3-methylsulfanylmethoxy-phenyl)-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL97206

SMILES COc1cccc2OC(c3cccc(OCSC)c3)c3c(ccc4NC(C)(C)C=C(C)c34)-c12

InChI Key InChIKey=PZGBWVRLVNGXMZ-UHFFFAOYSA-N

Data  6 KI  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50103249   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103249(10-Methoxy-2,2,4-trimethyl-5-(3-methylsulfanylmeth...)
Affinity DataKi:  4nMAssay Description:Binding affinity for glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103249(10-Methoxy-2,2,4-trimethyl-5-(3-methylsulfanylmeth...)
Affinity DataKi:  4nMAssay Description:Binding affinity towards glucocorticoid receptor (GR) by displacing [3H]-DexamethasoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103249(10-Methoxy-2,2,4-trimethyl-5-(3-methylsulfanylmeth...)
Affinity DataKi:  3.12E+3nMAssay Description:Binding affinity for androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103249(10-Methoxy-2,2,4-trimethyl-5-(3-methylsulfanylmeth...)
Affinity DataKi:  3.84E+3nMAssay Description:Binding affinity for mineralocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103249(10-Methoxy-2,2,4-trimethyl-5-(3-methylsulfanylmeth...)
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity for progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103249(10-Methoxy-2,2,4-trimethyl-5-(3-methylsulfanylmeth...)
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity towards progesterone receptor (PR) by displacing [3H]-progesterone.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103249(10-Methoxy-2,2,4-trimethyl-5-(3-methylsulfanylmeth...)
Affinity DataEC50:  9nMAssay Description:The effective concentration in CV-1 cells for glucocorticoid response element activation (GRE).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103249(10-Methoxy-2,2,4-trimethyl-5-(3-methylsulfanylmeth...)
Affinity DataEC50:  4nMAssay Description:Effective concentration in HepG2 cells transfected with LUC gene (E-sel-Luc).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103249(10-Methoxy-2,2,4-trimethyl-5-(3-methylsulfanylmeth...)
Affinity DataIC50:  16nMAssay Description:Repression activity of GR ligand with interleukin-6 receptor in native cell assay using dexamethasone was determined as maximal potencyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103249(10-Methoxy-2,2,4-trimethyl-5-(3-methylsulfanylmeth...)
Affinity DataIC50:  4nMAssay Description:Transcriptional repression activity in HEP G2 cells expressing glucocorticoid receptor compared to dexamethasoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103249(10-Methoxy-2,2,4-trimethyl-5-(3-methylsulfanylmeth...)
Affinity DataIC50:  9nMAssay Description:Transcriptional activation in CV-1 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103249(10-Methoxy-2,2,4-trimethyl-5-(3-methylsulfanylmeth...)
Affinity DataIC50:  140nMAssay Description:Glucocorticoid-induced aromatase activity in human skin fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed