BDBM50106026 (S)-2,2-Dimethyl-4-[4-(pyridin-3-yloxy)-benzenesulfonyl]-thiomorpholine-3-carboxylic acid hydroxyamide::CHEMBL318484

SMILES CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(Oc2cccnc2)cc1

InChI Key InChIKey=YTRMRJDVKQXSIU-INIZCTEOSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50106026   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106026((S)-2,2-Dimethyl-4-[4-(pyridin-3-yloxy)-benzenesul...)
Affinity DataIC50:  8.60E+3nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106026((S)-2,2-Dimethyl-4-[4-(pyridin-3-yloxy)-benzenesul...)
Affinity DataIC50:  5.70nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106026((S)-2,2-Dimethyl-4-[4-(pyridin-3-yloxy)-benzenesul...)
Affinity DataIC50:  0.0480nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106026((S)-2,2-Dimethyl-4-[4-(pyridin-3-yloxy)-benzenesul...)
Affinity DataIC50:  7.94nMAssay Description:Inhibition of TACE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106026((S)-2,2-Dimethyl-4-[4-(pyridin-3-yloxy)-benzenesul...)
Affinity DataIC50:  8.60E+3nMAssay Description:Inhibition of TACE (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106026((S)-2,2-Dimethyl-4-[4-(pyridin-3-yloxy)-benzenesul...)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of TACE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106026((S)-2,2-Dimethyl-4-[4-(pyridin-3-yloxy)-benzenesul...)
Affinity DataIC50:  7.90nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed