BDBM50107344 5-Isobutyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL137982

SMILES COc1cccc2OC(CC(C)C)c3c(ccc4NC(C)(C)C=C(C)c34)-c12

InChI Key InChIKey=LUJGLEQFDNFEOE-UHFFFAOYSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50107344   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107344(5-Isobutyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-...)
Affinity DataKi:  9.5nMAssay Description:Binding affinity towards glucocorticoid receptor (GR) by displacing [3H]-DexamethasoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107344(5-Isobutyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-...)
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity towards progesterone receptor (PR) by displacing [3H]-progesterone.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107344(5-Isobutyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-...)
Affinity DataEC50:  69nMAssay Description:Effective concentration in HepG2 cells transfected with LUC gene (E-sel-Luc).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107344(5-Isobutyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-...)
Affinity DataEC50:  223nMAssay Description:The effective concentration in CV-1 cells for glucocorticoid response element activation (GRE).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed