BDBM50107345 CHEMBL141426::[2-(10-Methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-5-yl)-ethyl]-dimethyl-amine

SMILES COc1cccc2OC(CCN(C)C)c3c(ccc4NC(C)(C)C=C(C)c34)-c12

InChI Key InChIKey=VCKAFJQJFFMCQM-UHFFFAOYSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50107345   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107345(CHEMBL141426 | [2-(10-Methoxy-2,2,4-trimethyl-2,5-...)
Affinity DataKi:  62nMAssay Description:Binding affinity towards glucocorticoid receptor (GR) by displacing [3H]-DexamethasoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107345(CHEMBL141426 | [2-(10-Methoxy-2,2,4-trimethyl-2,5-...)
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity towards progesterone receptor (PR) by displacing [3H]-progesterone.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107345(CHEMBL141426 | [2-(10-Methoxy-2,2,4-trimethyl-2,5-...)
Affinity DataEC50:  306nMAssay Description:Effective concentration in HepG2 cells transfected with LUC gene (E-sel-Luc).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107345(CHEMBL141426 | [2-(10-Methoxy-2,2,4-trimethyl-2,5-...)
Affinity DataEC50:  520nMAssay Description:The effective concentration in CV-1 cells for glucocorticoid response element activation (GRE).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed