BDBM50107360 2-(10-Methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-5-yl)-N-methyl-acetamide::CHEMBL138753

SMILES CNC(=O)CC1Oc2cccc(OC)c2-c2ccc3NC(C)(C)C=C(C)c3c12

InChI Key InChIKey=OKQVQYKHHUXADN-UHFFFAOYSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50107360   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107360(2-(10-Methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa...)
Affinity DataKi:  3.20E+3nMAssay Description:Binding affinity towards glucocorticoid receptor (GR) by displacing [3H]-DexamethasoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107360(2-(10-Methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa...)
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity towards progesterone receptor (PR) by displacing [3H]-progesterone.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107360(2-(10-Methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa...)
Affinity DataEC50: >5.00E+3nMAssay Description:Effective concentration in HepG2 cells transfected with LUC gene (E-sel-Luc).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107360(2-(10-Methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa...)
Affinity DataEC50: >5.00E+3nMAssay Description:The effective concentration in CV-1 cells for glucocorticoid response element activation (GRE).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed