BDBM50108615 CHEMBL3597958::US9695163, 35

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1cscc1-n1nccn1)c1csc(n1)C(C)(C)O

InChI Key InChIKey=OSWKJZVTRUEBIY-CHWSQXEVSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50108615   

TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50108615(CHEMBL3597958 | US9695163, 35)
Affinity DataIC50:  14nMT: 2°CAssay Description:Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50108615(CHEMBL3597958 | US9695163, 35)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at human orexin-1 receptor expressed in CHO cells assessed as inhibition of human orexin-A-induced Ca2+ flux preincubated for 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50108615(CHEMBL3597958 | US9695163, 35)
Affinity DataIC50:  14nMAssay Description:Antagonist activity at human orexin-2 receptor expressed in CHO cells assessed as inhibition of human orexin-A-induced Ca2+ flux preincubated for 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50108615(CHEMBL3597958 | US9695163, 35)
Affinity DataIC50: >1.00E+4nMT: 2°CAssay Description:Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...More data for this Ligand-Target Pair
In DepthDetails US Patent