BDBM50110165 CHEMBL2218589

SMILES Fc1ccc(cc1)-c1nnc2CN(CCn12)C(=O)c1cccc(c1Cl)C(F)(F)F

InChI Key InChIKey=CGXSPIMMMGDAPS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50110165   

TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50110165(CHEMBL2218589)
Affinity DataIC50:  14nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of BzATP-induced Ca2+ flux after 30 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50110165(CHEMBL2218589)
Affinity DataIC50:  6.39E+3nMAssay Description:Antagonist activity at rat P2X7 receptor assessed as inhibition of ATP-induced Ca2+ flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50110165(CHEMBL2218589)
Affinity DataIC50: >10nMAssay Description:Antagonist activity against human P2X7 receptor expressed in HEK293 cells by FLIPR based calcium accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed