BDBM50110170 CHEMBL3604425

SMILES C[C@H]1Cn2c(CN1C(=O)c1cccc(Cl)c1Cl)nnc2-c1cccc(F)n1

InChI Key InChIKey=IITDXWDZXDVZRA-JTQLQIEISA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50110170   

TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50110170(CHEMBL3604425)
Affinity DataIC50:  1.69E+3nMAssay Description:Antagonist activity at rat P2X7 receptor assessed as inhibition of ATP-induced Ca2+ flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50110170(CHEMBL3604425)
Affinity DataIC50:  23nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of BzATP-induced Ca2+ flux after 30 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed