BDBM50110171 CHEMBL3604426

SMILES COc1ccnc(c1)-c1nnc2CN([C@@H](C)Cn12)C(=O)c1cccc(Cl)c1Cl

InChI Key InChIKey=MULCYNKNDJVWBS-NSHDSACASA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50110171   

TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50110171(CHEMBL3604426)
Affinity DataIC50:  7.70nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of BzATP-induced Ca2+ flux after 30 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50110171(CHEMBL3604426)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]-astemizole from human ERG channel expressed in HEK293 cells by radioligand competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50110171(CHEMBL3604426)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at rat P2X7 receptor assessed as inhibition of ATP-induced Ca2+ flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed