BDBM50118029 3-Isopropyl-1-methanesulfonyl-4-(4-piperidin-1-yl-but-2-enoyl)-hexahydro-pyrrolo[3,2-b]pyrrol-2-one; hydrochloride::CHEMBL2368616
SMILES Cl.[H][C@@]12CCN(C(=O)\C=C\CN3CCCCC3)[C@@]1([H])[C@H](C(C)C)C(=O)N2S(C)(=O)=O
InChI Key InChIKey=NDNKNUMSTIMSHQ-URZKGLGPSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50118029
Affinity DataKi: 0.310nMAssay Description:The compound was evaluated for its binding affinity towards human neutrophil elastase (HNE)More data for this Ligand-Target Pair
Affinity DataKi: 0.310nM Kon: 0.00000207M-1s-1 Koff: 6.63E+3s-1Assay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
Affinity DataIC50: 670nMAssay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
Affinity DataIC50: <1.00E+5nMAssay Description:The compound was evaluated for its inhibitory activity against trypsin using selectivity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:The compound was evaluated for its inhibitory activity against dog neutrophil elastase using whole blood assayMore data for this Ligand-Target Pair
Affinity DataKoff: 6.63E+3s-1pH: 7.4Assay Description:Dissociation rate constant at pH 7.4 against ElastaseMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of neutrophil elastase in human whole blood using MeO-Succ-Ala-Ala-Pro-Val-pNA as substrate after 30 mins by colorimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:The compound was evaluated for its inhibitory activity against Chymotrypsinogen using selectivity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
Affinity DataKon: 2.06E+6M-1s-1pH: 7.4Assay Description:Association rate constant at pH 7.4.against ElastaseMore data for this Ligand-Target Pair
Affinity DataIC50: <1.00E+5nMAssay Description:The compound was evaluated for its inhibitory activity against cathepsin G using selectivity assayMore data for this Ligand-Target Pair