BDBM50128648 1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-piperidine-4-carboxylic acid hydroxyamide::1-benzyl-4-(4-(4-chlorophenoxy)phenylsulfonyl)-N-hydroxypiperidine-4-carboxamide::CHEMBL79433

SMILES ONC(=O)C1(CCN(Cc2ccccc2)CC1)S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1

InChI Key InChIKey=IMKDKHQDFFLOKK-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50128648   

TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Asahi Kasei Pharma

Curated by ChEMBL
LigandPNGBDBM50128648(1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of ADAMTS-4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50128648(1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Affinity DataIC50:  55nMAssay Description:Inhibition of Matrix metalloprotease-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50128648(1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-9.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50128648(1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Affinity DataIC50:  301nMAssay Description:In vitro inhibitory activity against tumor necrosis factor alpha converting enzyme (TACE).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50128648(1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Asahi Kasei Pharma

Curated by ChEMBL
LigandPNGBDBM50128648(1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Affinity DataIC50:  420nMAssay Description:Inhibition of ADAMTS-5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50128648(1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Affinity DataIC50:  7nMAssay Description:Inhibition of Matrix metalloprotease-14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50128648(1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50128648(1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Affinity DataIC50:  801nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50128648(1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Affinity DataIC50:  925nMAssay Description:Inhibition of Matrix metalloprotease-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50128648(1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed