BDBM50130656 CHEMBL321415::{4-[5-(4-Fluoro-phenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenyl-ethyl)-amine

SMILES CSc1nc(c([nH]1)-c1ccc(F)cc1)-c1ccnc(N[C@@H](C)c2ccccc2)c1

InChI Key InChIKey=VXPWQNBKEIVYIS-HNNXBMFYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50130656   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-University Tu£Bingen

Curated by ChEMBL
LigandPNGBDBM50130656(CHEMBL321415 | {4-[5-(4-Fluoro-phenyl)-2-methylsul...)
Affinity DataIC50:  1.93E+3nMAssay Description:Inhibition of p38 alpha MAPK in human whole blood assessed as suppression of LPS-induced TNF-alpha release by immunosorbent non-radioactive enzyme as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-University Tu£Bingen

Curated by ChEMBL
LigandPNGBDBM50130656(CHEMBL321415 | {4-[5-(4-Fluoro-phenyl)-2-methylsul...)
Affinity DataIC50:  50nMAssay Description:Inhibition of p38 alpha MAPK in human whole blood assessed as phosphorylation of ATF-2 by immunosorbent non-radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50130656(CHEMBL321415 | {4-[5-(4-Fluoro-phenyl)-2-methylsul...)
Affinity DataIC50:  44nMAssay Description:Inhibitory activity against induction of IL-1-beta release in PBMCsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50130656(CHEMBL321415 | {4-[5-(4-Fluoro-phenyl)-2-methylsul...)
Affinity DataIC50:  900nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 at 10 e-4 to 10 e-8 M concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50130656(CHEMBL321415 | {4-[5-(4-Fluoro-phenyl)-2-methylsul...)
Affinity DataIC50:  370nMAssay Description:Inhibitory activity against TNF-alpha release in PBM cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed