BDBM50130656 CHEMBL321415::{4-[5-(4-Fluoro-phenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenyl-ethyl)-amine
SMILES CSc1nc(c([nH]1)-c1ccc(F)cc1)-c1ccnc(N[C@@H](C)c2ccccc2)c1
InChI Key InChIKey=VXPWQNBKEIVYIS-HNNXBMFYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50130656
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-University Tu£Bingen
Curated by ChEMBL
Eberhard-Karls-University Tu£Bingen
Curated by ChEMBL
Affinity DataIC50: 1.93E+3nMAssay Description:Inhibition of p38 alpha MAPK in human whole blood assessed as suppression of LPS-induced TNF-alpha release by immunosorbent non-radioactive enzyme as...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-University Tu£Bingen
Curated by ChEMBL
Eberhard-Karls-University Tu£Bingen
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of p38 alpha MAPK in human whole blood assessed as phosphorylation of ATF-2 by immunosorbent non-radioactive enzyme assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Eberhard-Karls-University T£Bingen
Curated by ChEMBL
Eberhard-Karls-University T£Bingen
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Inhibitory activity against induction of IL-1-beta release in PBMCsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Eberhard-Karls-University T£Bingen
Curated by ChEMBL
Eberhard-Karls-University T£Bingen
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 at 10 e-4 to 10 e-8 M concentrationMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Eberhard-Karls-University T£Bingen
Curated by ChEMBL
Eberhard-Karls-University T£Bingen
Curated by ChEMBL
Affinity DataIC50: 370nMAssay Description:Inhibitory activity against TNF-alpha release in PBM cellsMore data for this Ligand-Target Pair