BDBM50131229 CHEMBL3634773::US9260425, 368

SMILES C1CN(CCN1)c1cccc(n1)-c1n[nH]c2cnc(cc12)-n1ccnc1

InChI Key InChIKey=BDYUVBLOKBRWER-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50131229   

TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50131229(CHEMBL3634773 | US9260425, 368)
Affinity DataKi:  0.650nMAssay Description:Inhibition of Pim3 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50131229(CHEMBL3634773 | US9260425, 368)
Affinity DataKi:  1.80nMAssay Description:Inhibition of Pim1 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50131229(CHEMBL3634773 | US9260425, 368)
Affinity DataKi:  1.82nMpH: 7.2Assay Description:PIM-1, PIM-2, and PIM-3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50131229(CHEMBL3634773 | US9260425, 368)
Affinity DataKi:  5.40nMAssay Description:Inhibition of Pim2 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed