BDBM50131808 CHEMBL3634341

SMILES Cc1cc(Cl)cnc1C(=O)Nc1ccc(F)c(c1)[C@@]1(C)N=C(N)CO[C@@H]1F

InChI Key InChIKey=CQTYPCIWXALTQA-ZWKOTPCHSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50131808   

TargetCytochrome P450 2D6(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50131808(CHEMBL3634341)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CYP2D6 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50131808(CHEMBL3634341)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of BACE1 in human SKNBE2 cells expressing wild type human APP695 assessed as reduction in amyloid beta-42 production after 18 hrs by sandw...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50131808(CHEMBL3634341)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of BACE1 (unknown origin) using APP Swedish mutant harboring Lys-Met/Asn-Leu mutation in beta-secretase cleavage site as substrate by FRET...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed