BDBM50135122 CHEMBL3746783

SMILES COc1ccc(-c2nc3c(NCC4CCN(C)CC4)c(Cl)cnc3[nH]2)c(C)c1

InChI Key InChIKey=WYXKVCBANXZZQD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50135122   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50135122(CHEMBL3746783)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of N-terminal GST-fused recombinant JAK2 (831 to 1132 residues) (unknown origin) expressed in insect cells using 5FAM-GEEPLYWSFPAKKK-NH2 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50135122(CHEMBL3746783)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of N-terminal GST-fused recombinant JAK3 (781 to 1124 residues) (unknown origin) expressed in insect cells using 5FAM-GEEPLYWSFPAKKK-NH2 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50135122(CHEMBL3746783)
Affinity DataIC50:  36nMAssay Description:Inhibition of N-terminal GST-fused human recombinant JAK1 (866 to 1154 residues) expressed in insect cells using FITC-C6-KKHTDDGYMPMSPGVA-NH2 as subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed