BDBM50135130 CHEMBL3746463

SMILES COc1cc(F)c(cc1OC)-c1nc2c(NCC3CCNCC3)c(Cl)cnc2[nH]1

InChI Key InChIKey=IRGAIDAWHGYOKD-UHFFFAOYSA-N

Data  8 IC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50135130   

TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50135130(CHEMBL3746463)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of N-terminal GST-fused recombinant JAK3 (781 to 1124 residues) (unknown origin) expressed in insect cells using 5FAM-GEEPLYWSFPAKKK-NH2 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50135130(CHEMBL3746463)
Affinity DataIC50:  39nMAssay Description:Inhibition of JAK1 in human NCI-H1975 cells assessed as reduction in STAT3 phosphorylation after 2 hrsMore data for this Ligand-Target Pair
TargetAurora kinase B(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50135130(CHEMBL3746463)
Affinity DataIC50:  132nMAssay Description:Inhibition of GST-INCENP activated N-terminal 6His-tagged human recombinant full length Aurora B (1 to 344 residues) expressed in baculovirus express...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50135130(CHEMBL3746463)
Affinity DataIC50:  2nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50135130(CHEMBL3746463)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant Tyk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50135130(CHEMBL3746463)
Affinity DataIC50:  22nMAssay Description:Inhibition of N-terminal GST-fused human recombinant JAK1 (866 to 1154 residues) expressed in insect cells using FITC-C6-KKHTDDGYMPMSPGVA-NH2 as subs...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50135130(CHEMBL3746463)
Affinity DataIC50: >2.20E+4nMAssay Description:Inhibition of N-terminal GST-fused recombinant JAK2 (831 to 1132 residues) (unknown origin) expressed in insect cells using 5FAM-GEEPLYWSFPAKKK-NH2 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50135130(CHEMBL3746463)
Affinity DataIC50:  114nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant full length CDK2 (1 to 304 residues)/Cyclin E1 (1 to 410 residues) expressed in insect cells u...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed