BDBM50135451 (2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroethyl-phenyl)-3-methyl-octa-2,4,6-trienoic acid::CHEMBL133896

SMILES CCOc1c(cc(cc1\C(C)=C/C=C/C(/C)=C/C(O)=O)C(F)(F)C(F)(F)F)C(C)C

InChI Key InChIKey=IXJIVOFEKLAPRC-GNFXPBCZSA-N

Data  6 KI  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50135451   

TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135451((2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroet...)
Affinity DataKi:  6.30nMAssay Description:Binding affinity against RXR alpha receptor using [3H]-9-cis-RA as radioligand in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor RXR-gamma(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135451((2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroet...)
Affinity DataKi:  7.70nMAssay Description:Binding affinity against RXR gamma receptor using [3H]-9-cis-RA as radioligand in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor RXR-beta(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135451((2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroet...)
Affinity DataKi:  8.5nMAssay Description:Displacement of [3H]-9-cis-RA from RXR beta receptor in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135451((2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroet...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity against RAR gamma receptor using [3H]-ATRA as radioligand in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135451((2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroet...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity against RAR alpha receptor using [3H]-ATRA as radioligand in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor beta(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135451((2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroet...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity against RAR beta receptor using [3H]-ATRA as radioligand in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135451((2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroet...)
Affinity DataEC50:  92nMAssay Description:In vitro agonistic activity against PPAR gamma along with 100 nM BRL49653More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135451((2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroet...)
Affinity DataEC50:  0.700nMAssay Description:In vitro anatagonist activity against RXR alpha in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135451((2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroet...)
Affinity DataEC50:  99nMAssay Description:In vitro agonist efficacy against PPAR gamma along with 100 nM BRL49653More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135451((2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroet...)
Affinity DataIC50:  5.30nMAssay Description:In vitro anatagonist activity against RXR alpha in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed