BDBM50135578 4-{3-[(S)-3-(3,4-Difluoro-phenyl)-2-methyl-propionylamino]-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl}-benzamide::CHEMBL130093

SMILES C[C@@H](Cc1ccc(F)c(F)c1)C(=O)NC1N=C(c2ccc(cc2)C(N)=O)c2ccccc2N(C)C1=O

InChI Key InChIKey=XVYHWQOGORTPLY-JMTKMGNOSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50135578   

TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL

LigandBDBM50135578(4-{3-[(S)-3-(3,4-Difluoro-phenyl)-2-methyl-propion...)Copy SMILESCopy InChI

Affinity DataIC50:  0.490nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
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Ligand InfoCHEMBLPC cidPC sidSimilars

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