BDBM50137733 (1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[(pyrazine-2-carbonyl)-amino]-butyrylamino}-butyryl)-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid [1-((S)-cyclopropylaminooxalyl)-butyl]-amide::CHEMBL86453

SMILES CCC[C@H](NC(=O)[C@@H]1[C@H]2CCC[C@H]2CN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)c1cnccn1)C(C)C)C(C)(C)C)C(=O)C(=O)NC1CC1

InChI Key InChIKey=KOKNYEMMHABSGG-RKISWGBFSA-N

Data  11 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50137733   

TargetCathepsin B(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137733((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi:  1.60nMAssay Description:Inhibitory activity of the compound against cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137733((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi:  80nMAssay Description:Inhibition of HCV NS3 protease in the pNA based inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137733((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi:  84nMAssay Description:Binding affinity of the compound towards Protease using PNA assay in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137733((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi:  154nMAssay Description:Inhibitory activity of the compound against cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137733((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi:  492nMAssay Description:Inhibitory activity of the compound against cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137733((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi:  1.60E+3nMAssay Description:Binding affinity towards human cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137733((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity towards human plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypsin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137733((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity towards human trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137733((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity towards human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137733((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity towards human ChymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137733((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi:  1.54E+5nMAssay Description:Binding affinity towards human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137733((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity of the compound against ChymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137733((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataIC50:  2.21E+3nMAssay Description:Inhibitory activity of the compound against Protease using replicon assay in rats at 25 microM concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed