BDBM50138641 2-[3-(4-Chloro-phenyl)-isoxazol-5-yl]-8-methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]octane::CHEMBL328415

SMILES CN1C2CCC1C(C(C2)c1ccc(C)cc1)c1cc(no1)-c1ccc(Cl)cc1

InChI Key InChIKey=MUVQRHMVRFZUGP-UHFFFAOYSA-N

Data  5 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50138641   

TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50138641(2-[3-(4-Chloro-phenyl)-isoxazol-5-yl]-8-methyl-3-p...)
Affinity DataKi:  8.60nMAssay Description:Displacement of [3H]WIN35428 from Sprague-Dawley rat brain DAT after 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50138641(2-[3-(4-Chloro-phenyl)-isoxazol-5-yl]-8-methyl-3-p...)
Affinity DataKi:  9.70nMAssay Description:Inhibition of [3H]DA uptake at wild type human DAT expressed in African green monkey COS7 cells after 5 mins by beta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50138641(2-[3-(4-Chloro-phenyl)-isoxazol-5-yl]-8-methyl-3-p...)
Affinity DataKi:  27nMAssay Description:Inhibition of [3H]WIN5428 uptake at wild type human DAT expressed in African green monkey COS7 cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50138641(2-[3-(4-Chloro-phenyl)-isoxazol-5-yl]-8-methyl-3-p...)
Affinity DataKi:  3.99E+3nMAssay Description:Binding affinity towards norepinephrine transporter was determined using [3H]nisoxetine radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50138641(2-[3-(4-Chloro-phenyl)-isoxazol-5-yl]-8-methyl-3-p...)
Affinity DataKi:  2.91E+4nMAssay Description:Displacement of [3H]citalopram from Sprague-Dawley rat brain SERT after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50138641(2-[3-(4-Chloro-phenyl)-isoxazol-5-yl]-8-methyl-3-p...)
Affinity DataIC50:  6.98E+3nMAssay Description:Inhibition of norepinephrine transporter (NET) determined using [3H]nisoxetine radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50138641(2-[3-(4-Chloro-phenyl)-isoxazol-5-yl]-8-methyl-3-p...)
Affinity DataIC50:  8.74nMAssay Description:Inhibitory concentration required to inhibit dopamine transporter DAT was determined by using [3H]WIN-35428 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50138641(2-[3-(4-Chloro-phenyl)-isoxazol-5-yl]-8-methyl-3-p...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory concentration required to inhibit serotonin transporter 5-HTT was determined by using [3H]paroxetine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed