BDBM50140862 5-Benzyl-4-{4-[2-(3,4-difluoro-phenyl)-ethyl]-piperazin-1-yl}-5H-pyrido[3',4':4,5]pyrrolo[3,2-d]pyrimidine::CHEMBL26081

SMILES Fc1ccc(CCN2CCN(CC2)c2ncnc3c4cnccc4n(Cc4ccccc4)c23)cc1F

InChI Key InChIKey=HQAXHHVZNNOKSS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50140862   

TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140862(5-Benzyl-4-{4-[2-(3,4-difluoro-phenyl)-ethyl]-pipe...)
Affinity DataIC50:  545nMAssay Description:In vitro inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Mus musculus (Mouse))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140862(5-Benzyl-4-{4-[2-(3,4-difluoro-phenyl)-ethyl]-pipe...)
Affinity DataIC50:  8.40E+3nMAssay Description:In vitro inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140862(5-Benzyl-4-{4-[2-(3,4-difluoro-phenyl)-ethyl]-pipe...)
Affinity DataIC50:  48nMAssay Description:Inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in single-dose potentiation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Mus musculus (Mouse))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140862(5-Benzyl-4-{4-[2-(3,4-difluoro-phenyl)-ethyl]-pipe...)
Affinity DataIC50:  1.11E+3nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed