BDBM50146471 CHEMBL431226::N-{1-(1,4-Dioxa-spiro[4.5]dec-8-yl)-2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-ethyl}-N-hydroxy-formamide

SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)CC(C2CCC3(CC2)OCCO3)N(O)C=O)c2ccccc2n1

InChI Key InChIKey=IDKUTWZTCGVYET-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50146471   

TargetMatrix metalloproteinase-17(Homo sapiens (Human))
Kaken Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50146471(CHEMBL431226 | N-{1-(1,4-Dioxa-spiro[4.5]dec-8-yl)...)
Affinity DataIC50:  220nMAssay Description:Inhibition of matrix metalloproteinase-17More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Kaken Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50146471(CHEMBL431226 | N-{1-(1,4-Dioxa-spiro[4.5]dec-8-yl)...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Kaken Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50146471(CHEMBL431226 | N-{1-(1,4-Dioxa-spiro[4.5]dec-8-yl)...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Kaken Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50146471(CHEMBL431226 | N-{1-(1,4-Dioxa-spiro[4.5]dec-8-yl)...)
Affinity DataIC50:  280nMAssay Description:Inhibition of matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Kaken Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50146471(CHEMBL431226 | N-{1-(1,4-Dioxa-spiro[4.5]dec-8-yl)...)
Affinity DataIC50:  15nMAssay Description:Inhibition of Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Kaken Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50146471(CHEMBL431226 | N-{1-(1,4-Dioxa-spiro[4.5]dec-8-yl)...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of matrix metalloproteinase-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed