BDBM50147620 CHEMBL3769507
SMILES CCn1cc(-c2cccc(c2)C(F)(F)F)c2sc(cc2c1=O)C(=N)NC1CCS(=O)(=O)CC1
InChI Key InChIKey=WRUWGLUCNBMGPS-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50147620
Affinity DataKi: 2nMAssay Description:Binding affinity to human partial length BRD9 (R130 to V259 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
Affinity DataKd: 148nMAssay Description:Binding affinity to recombinant human His-tagged BRD7 (129 to 250 residues) expressed in Escherichia coli BL21 DE3 assessed as dissociation constant ...More data for this Ligand-Target Pair
Affinity DataKd: 398nMAssay Description:Binding affinity to BRD7 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 2nMAssay Description:Binding affinity to BRD9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of BRD4 bromodomain 1 (unknown origin) incubated in dark for 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKd: 37nMAssay Description:Binding affinity to recombinant human His-tagged BRD9 (134 to 239 residues) expressed in Escherichia coli BL21 DE3 assessed as dissociation constant ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of BRD9 in human HUT78 cells incubated for 45 mins by chemoproteomic competition binding assayMore data for this Ligand-Target Pair
TargetChromatin remodeling regulator CECR2(Homo sapiens (Human))
Glaxosmithkline R&D
Curated by ChEMBL
Glaxosmithkline R&D
Curated by ChEMBL
Affinity DataIC50: 196nMAssay Description:Inhibition of BRD3 in human HUT78 cells incubated for 45 mins by chemoproteomic competition binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.05E+3nMAssay Description:Binding affinity to partial length human BRD7 by BROMOscan assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of BRD4 bromodomain 1 (unknown origin) incubated in dark for 30 mins by TR-FRET assayMore data for this Ligand-Target Pair