BDBM50148549 4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-benzenesulfonamide::4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methylbenzenesulfonamide::CHEMBL3770173::OF 1::OF-1

SMILES COc1cc2n(C)c(=O)n(C)c2cc1NS(=O)(=O)c1ccc(Br)cc1C

InChI Key InChIKey=YUNQZQREIHWDQT-UHFFFAOYSA-N

Data  10 IC50  3 Kd

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50148549   

TargetBromodomain-containing protein 1(Homo sapiens (Human))
Oxford University

LigandPNGBDBM50148549(4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-ox...)
Affinity DataIC50:  1.20E+3nMpH: 7.4 T: 2°CAssay Description:Assays were performed as described previously with minor modifications(Philpott et al., 2011). All reagents were diluted in 25 mM HEPES, 100 mM NaCl,...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Oxford University

LigandPNGBDBM50148549(4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-ox...)
Affinity DataIC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:Assays were performed as described previously with minor modifications(Philpott et al., 2011). All reagents were diluted in 25 mM HEPES, 100 mM NaCl,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeregrin(Homo sapiens (Human))
Oxford University

LigandPNGBDBM50148549(4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-ox...)
Affinity DataIC50:  270nMpH: 7.4 T: 2°CAssay Description:Assays were performed as described previously with minor modifications(Philpott et al., 2011). All reagents were diluted in 25 mM HEPES, 100 mM NaCl,...More data for this Ligand-Target Pair
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
Oxford University

LigandPNGBDBM50148549(4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-ox...)
Affinity DataIC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:Assays were performed as described previously with minor modifications(Philpott et al., 2011). All reagents were diluted in 25 mM HEPES, 100 mM NaCl,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeregrin(Homo sapiens (Human))
Oxford University

LigandPNGBDBM50148549(4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-ox...)
Affinity DataIC50:  270nMAssay Description:Inhibition of BRPF1B (unknown origin) by Alpha Screen assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 1(Homo sapiens (Human))
Oxford University

LigandPNGBDBM50148549(4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-ox...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of BRPF2 BRD1 (unknown origin) by Alpha Screen assayMore data for this Ligand-Target Pair
TargetPeregrin(Homo sapiens (Human))
Oxford University

LigandPNGBDBM50148549(4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-ox...)
Affinity DataIC50:  282nMAssay Description:Inhibition of human BRD4 BD1 (67 to 152 residues) preincubated for 15 mins followed by addition of C-terminal biotinylated synthetic K5,8,12,16 tetra...More data for this Ligand-Target Pair
TargetBromodomain and PHD finger-containing protein 3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50148549(4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-ox...)
Affinity DataKd:  2.40E+3nMAssay Description:Binding affinity to BRPF3 (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 1(Homo sapiens (Human))
Oxford University

LigandPNGBDBM50148549(4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-ox...)
Affinity DataKd:  500nMAssay Description:Binding affinity to BRPF2 (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 1(Homo sapiens (Human))
Oxford University

LigandPNGBDBM50148549(4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-ox...)
Affinity DataIC50:  1.68E+3nMAssay Description:Inhibition of human BRD4 BD1 (67 to 152 residues) preincubated for 15 mins followed by addition of C-terminal biotinylated synthetic K5,8,12,16 tetra...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 1(Homo sapiens (Human))
Oxford University

LigandPNGBDBM50148549(4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-ox...)
Affinity DataIC50:  128nMAssay Description:Inhibition of human BRD4 BD1 (67 to 152 residues) preincubated for 15 mins followed by addition of C-terminal biotinylated synthetic K5,8,12,16 tetra...More data for this Ligand-Target Pair
TargetPeregrin(Homo sapiens (Human))
Oxford University

LigandPNGBDBM50148549(4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-ox...)
Affinity DataIC50:  383nMAssay Description:Inhibition of human BRD4 BD1 (67 to 152 residues) preincubated for 15 mins followed by addition of C-terminal biotinylated synthetic K5,8,12,16 tetra...More data for this Ligand-Target Pair
TargetPeregrin(Homo sapiens (Human))
Oxford University

LigandPNGBDBM50148549(4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-ox...)
Affinity DataKd:  100nMAssay Description:Binding affinity to BRPF1B (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair