BDBM50152595 CHEMBL3780091

SMILES N[C@H]1CC[C@H](CC1)Nc1cc[nH]c(=O)c1-c1nc2ccccc2[nH]1

InChI Key InChIKey=JLWGOAGEDWMEBT-TXEJJXNPSA-N

Data  12 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50152595   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50:  4nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50:  3nMAssay Description:Inhibition of JAK1 in human PBMC cells assessed as inhibition of IL-6-induced MCP1 secretionMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50:  48nMAssay Description:Inhibition of JAK2 in human CD34+ cells assessed as inhibition of EPO-mediated cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50:  2nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase BRSK1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50:  2nMAssay Description:Inhibition of BRSK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50:  5nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-AMP-activated protein kinase catalytic subunit alpha-1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of AMPKa1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50:  9nMAssay Description:Inhibition of PDGFRA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50:  4nMAssay Description:Inhibition of SNF1LK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed