BDBM50154894 CHEMBL3775338::US10273244, Example 28::US10584135, Example 28

SMILES Cc1ncoc1-c1nnc(SCCCN2CC3CCN(C3C2)c2cc(Cl)cc(Cl)c2)n1C

InChI Key InChIKey=JYMJYHGKDBZGLV-UHFFFAOYSA-N

Data  6 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50154894   

TargetD(3) dopamine receptor(Homo sapiens (Human))
Indivior

US Patent
LigandPNGBDBM50154894(CHEMBL3775338 | US10273244, Example 28 | US1058413...)
Affinity DataKi:  0.417nMAssay Description:3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(3) dopamine receptor(Homo sapiens (Human))
Indivior

US Patent
LigandPNGBDBM50154894(CHEMBL3775338 | US10273244, Example 28 | US1058413...)
Affinity DataKi:  0.417nMAssay Description:[3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Indivior

US Patent
LigandPNGBDBM50154894(CHEMBL3775338 | US10273244, Example 28 | US1058413...)
Affinity DataKi:  10.5nMAssay Description:CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were re-suspended ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Indivior

US Patent
LigandPNGBDBM50154894(CHEMBL3775338 | US10273244, Example 28 | US1058413...)
Affinity DataKi:  10.5nMAssay Description:Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...More data for this Ligand-Target Pair
In DepthDetails US Patent