BDBM50154898 CHEMBL3774431::US10273244, Example 61::US10584135, Example 61

SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(F)cc2)nnc1C1CCCCC1

InChI Key InChIKey=XUKSGYGUDPUQCB-UHFFFAOYSA-N

Data  8 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50154898   

TargetD(3) dopamine receptor(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154898(CHEMBL3774431 | US10273244, Example 61 | US1058413...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation counter metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154898(CHEMBL3774431 | US10273244, Example 61 | US1058413...)
Affinity DataKi:  0.407nMAssay Description:3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(3) dopamine receptor(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154898(CHEMBL3774431 | US10273244, Example 61 | US1058413...)
Affinity DataKi:  0.407nMAssay Description:[3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(3) dopamine receptor(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154898(CHEMBL3774431 | US10273244, Example 61 | US1058413...)
Affinity DataKi:  0.794nMAssay Description:Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation counter metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154898(CHEMBL3774431 | US10273244, Example 61 | US1058413...)
Affinity DataKi:  0.794nMAssay Description:Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation counter metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154898(CHEMBL3774431 | US10273244, Example 61 | US1058413...)
Affinity DataKi:  39.8nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor expressed in CHO-K1 cell membranes after 120 mins by liquid scintillation counter meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154898(CHEMBL3774431 | US10273244, Example 61 | US1058413...)
Affinity DataKi:  398nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor expressed in CHO-K1 cell membranes after 120 mins by liquid scintillation counter meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154898(CHEMBL3774431 | US10273244, Example 61 | US1058413...)
Affinity DataKi:  398nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor expressed in CHO-K1 cell membranes after 120 mins by liquid scintillation counter meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154898(CHEMBL3774431 | US10273244, Example 61 | US1058413...)
Affinity DataIC50: >100nMAssay Description:Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154898(CHEMBL3774431 | US10273244, Example 61 | US1058413...)
Affinity DataIC50:  316nMAssay Description:Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed