BDBM50155250 3-[3-(2,3-Dihydro-1H-isoindol-5-ylcarbamoyl)-propionylamino]-3-phenyl-propionic acid; hydrochloride::CHEMBL536269

SMILES OC(=O)CC(NC(=O)CCC(=O)Nc1ccc2CNCc2c1)c1ccccc1

InChI Key InChIKey=DBOQCKFLGLRZBD-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50155250   

TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
A.V. Bogatsky Physico-Chemical Institute Of The National Academy Of Sciences Of Ukraine

Curated by ChEMBL
LigandPNGBDBM50155250(3-[3-(2,3-Dihydro-1H-isoindol-5-ylcarbamoyl)-propi...)
Affinity DataKi:  4.20nMAssay Description:In vitro binding affinity for FITC-labeled fibrinogen binding to alphaIIb-beta3 receptor of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
A.V. Bogatsky Physico-Chemical Institute Of The National Academy Of Sciences Of Ukraine

Curated by ChEMBL
LigandPNGBDBM50155250(3-[3-(2,3-Dihydro-1H-isoindol-5-ylcarbamoyl)-propi...)
Affinity DataIC50:  860nMAssay Description:In vitro inhibition of human platelet aggregation in platelet rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-3/beta-3(Homo sapiens (Human))
A.V. Bogatsky Physico-Chemical Institute Of The National Academy Of Sciences Of Ukraine

Curated by ChEMBL
LigandPNGBDBM50155250(3-[3-(2,3-Dihydro-1H-isoindol-5-ylcarbamoyl)-propi...)
Affinity DataIC50:  8.30nMAssay Description:Antagonist activity at FITC-tagged alpha3beta3 integrin in human platelet assessed as reduction of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
A.V. Bogatsky Physico-Chemical Institute Of The National Academy Of Sciences Of Ukraine

Curated by ChEMBL
LigandPNGBDBM50155250(3-[3-(2,3-Dihydro-1H-isoindol-5-ylcarbamoyl)-propi...)
Affinity DataIC50:  8.30nMAssay Description:In vitro inhibition of FITC-labeled fibrinogen binding to alphaIIb-beta3 receptor of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-3/beta-3(Homo sapiens (Human))
A.V. Bogatsky Physico-Chemical Institute Of The National Academy Of Sciences Of Ukraine

Curated by ChEMBL
LigandPNGBDBM50155250(3-[3-(2,3-Dihydro-1H-isoindol-5-ylcarbamoyl)-propi...)
Affinity DataIC50:  860nMAssay Description:Antagonist activity at FITC-tagged alpha3beta3 integrin in human platelet rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
A.V. Bogatsky Physico-Chemical Institute Of The National Academy Of Sciences Of Ukraine

Curated by ChEMBL
LigandPNGBDBM50155250(3-[3-(2,3-Dihydro-1H-isoindol-5-ylcarbamoyl)-propi...)
Affinity DataIC50:  270nMAssay Description:In vitro inhibition of human platelet aggregation in suspensionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed