BDBM50156070 CHEMBL366217::N-(4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl)-2-hydroxybenzamide::N-(4-chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)phenyl)-2-hydroxybenzamide::N-[4-Chloro-2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phenyl]-2-hydroxy-benzamide

SMILES Oc1ccccc1C(=O)Nc1ccc(Cl)cc1CN1C(=O)c2ccccc2C1=O

InChI Key InChIKey=UFOUABRZSDGGAZ-UHFFFAOYSA-N

Data  2 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50156070   

TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50156070(CHEMBL366217 | N-(4-Chloro-2-[(1,3-dioxo-1,3-dihyd...)
Affinity DataEC50: <1.00E+3nMAssay Description:Activity at rat mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156070(CHEMBL366217 | N-(4-Chloro-2-[(1,3-dioxo-1,3-dihyd...)
Affinity DataEC50:  300nMAssay Description:Effective concentration against metabotropic glutamate receptor 5 of human transfected into CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156070(CHEMBL366217 | N-(4-Chloro-2-[(1,3-dioxo-1,3-dihyd...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]-MethoxyPEPy from human mGlu5 receptor expressed in HEK293 cell membranes after 8 hrs by micro beta scintillation counting analys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156070(CHEMBL366217 | N-(4-Chloro-2-[(1,3-dioxo-1,3-dihyd...)
Affinity DataEC50:  150nMAssay Description:Positive allosteric modulation of human mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50156070(CHEMBL366217 | N-(4-Chloro-2-[(1,3-dioxo-1,3-dihyd...)
Affinity DataIC50:  930nMAssay Description:Displacement of [3H]-MethoxyPEPy from mGlu5 receptor in primary rat astrocytes after 8 hrs by micro beta scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50156070(CHEMBL366217 | N-(4-Chloro-2-[(1,3-dioxo-1,3-dihyd...)
Affinity DataEC50:  250nMAssay Description:Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed