BDBM50157254 5-[(4-Cyano-benzyloxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-2''-trifluoromethyl-biphenyl-2-carbonitrile::CHEMBL360525

SMILES Cn1cncc1C(OCc1ccc(cc1)C#N)c1ccc(C#N)c(c1)-c1ccccc1C(F)(F)F

InChI Key InChIKey=OVHHNUWVHOKUKE-UHFFFAOYSA-N

Data  2 IC50  1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50157254   

TargetGeranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Abbott Laboratories

Curated by ChEMBL

LigandBDBM50157254(5-[(4-Cyano-benzyloxy)-(3-methyl-3H-imidazol-4-yl)...)Copy SMILESCopy InChI

Affinity DataIC50:  310nMAssay Description:Inhibition of Bovine Geranyl geranyl transeferaseMore data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Mus musculus)
Abbott Laboratories

Curated by ChEMBL

LigandBDBM50157254(5-[(4-Cyano-benzyloxy)-(3-methyl-3H-imidazol-4-yl)...)Copy SMILESCopy InChI

Affinity DataEC50:  85nMAssay Description:Effective concentration against H-ras processing in transformed NIH3T3 cellsMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Abbott Laboratories

Curated by ChEMBL

LigandBDBM50157254(5-[(4-Cyano-benzyloxy)-(3-methyl-3H-imidazol-4-yl)...)Copy SMILESCopy InChI

Affinity DataIC50:  0.800nMAssay Description:Inhibition of Bovine farnesyl transeferaseMore data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI